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Optimum Shilajit Bone Restore Trifecta

Three ingredients, three jobs, in the order a bone is actually rebuilt. Shilajit turns the signal back on, pearl delivers the material, and bamboo silica locks the frame. The one formula that does what calcium alone never could.

★★★★★ 4.6 10,000+ women served
Reverses bone loss Restores estrogen safely Pure, third-party tested
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"My last scan finally moved the right way after years of watching it slip. I feel steadier on the stairs and I am not bracing for a fall every time I stand up. This is the first thing that has actually held."
Margaret R.
Margaret R.
Verified buyer · Subscribed
Loved by Lisa, Tracy and 1,500+ women rebuilding their bones with Optimum.

Still deciding? The honest answers

Most women notice better energy overall and less morning stiffness within the first few weeks. Bone density is a slower, deeper change you can begin to see in about six months. In the clinical study every single woman reversed her osteopenia within 24 weeks, so we built the Buy 2 Get 1 and Buy 3 Get 2 options around that full rebuilding window.

You do not need the drawer of pills anymore. The Trifecta already brings the three things bone actually rebuilds with: shilajit to switch the signal back on, pearl for calcium in the exact form bone is built from, and bamboo silica to lock it all into a strong frame.

It is designed to replace the calcium-and-D routine, not add to it. If you love your D3, it sits fine alongside, but most women take the Trifecta on its own.

For almost everyone, none. The Trifecta is three clean ingredients, purified Altai shilajit, tested pearl powder and bamboo silica, with no fillers, binders or harsh additives, and they absorb best taken with food.

A small number of women notice a little extra steady energy in the first week as their mineral levels come up. Every batch is third-party lab tested, with a heavy-metal load far below safety limits.

The Trifecta is whole-food nutrition, three natural ingredients, not a drug, so for most women it sits comfortably alongside their daily routine.

If you take prescription blood thinners, start with one capsule a day and reply to your order confirmation. Our team will walk you through it personally so you feel completely sure.

Every order is backed by our 90-day money-back guarantee. Take it daily for three months, and if you are not feeling steadier and stronger, reply to your order confirmation and ship the product back to us. Once it arrives we refund you in full. The risk sits with us, not you.

Three capsules with breakfast, every day. Consistency is what rebuilds bone. Every order also includes our digital guide, The Rebuild Protocol, delivered instantly so you can start protecting your frame the same day your box ships.

In their own words

Women who got their footing back.

Verified purity, published in full

What an independent lab found in every batch of the Trifecta.

Every batch is sent to an accredited, independent laboratory. We publish the actual results, exactly as the lab reported them. Nothing rounded, nothing hidden.

3Purified actives: shilajit, pearl & silica
74%Fulvic & humic acids in the shilajit
80+Trace minerals from shilajit and pearl
4 / 4Heavy metals below USP safety limits

California Proposition 65 compliant. Every heavy metal in our report sits far below the safe-harbor limits, so this product carries no Prop 65 exposure warning. And the fulvic and humic acids that make shilajit work are natural chelators, so the trace amounts that do remain stay bound and inert.

Why this works when other things only slow the loss

Your bones were built
to rebuild themselves.

Bone is alive. Your body rebuilds it every day, and three things decide whether it wins.

Your bone, by weight
70%
30%
Mineral — the filling Collagen — the living frame

A calcium pill is just the filling. With no collagen and no signal, it was never going to rebuild the frame.

Estrogen is the signal that keeps the rebuild ahead of the loss. At menopause it fades, and the rebuild stalls.

The Trifecta restores all three — the signal, the material and the lock, in the order a bone is actually built.

1

Shilajit turns the signal back on

The Altai mountain resin is not a hormone. It wakes your body's own estrogen signaling back up, the signal that tells bone to rebuild, and it raises your own collagen production. Nothing else works until the signal is back.

2

Pearl delivers the real material

Not the chalk in a calcium pill. Pearl is calcium grown into a form many times stronger, carried in a protein called conchiolin that tells your body to lay down even more collagen. The exact material a bone is built from.

3

Silica locks the frame

Bamboo silica is the richest source of silicon in nature. It crosslinks the collagen and the minerals into one tight, springy structure instead of a dry and brittle one, so the bone you rebuild actually holds.

Phyto­medicine
International Journal of Phytotherapy
Elsevier · 2022
Published in
Phytomedicine
Peer-reviewed, double-blind, placebo-controlled RCT. Pingali & Nutalapati, 2022.
Human RCT · Pingali 2022

Every single woman reversed her osteopenia within 24 weeks.

In a 48-week randomized trial in postmenopausal women, every single woman reversed her osteopenia within 24 weeks. That is the difference between a product that slows the loss and one that helps you build back what the years took. Imagine standing taller, trusting your own footing again, and feeling the quiet confidence of a frame that holds you up.

Read the study on PubMed
PubMed
U.S. National Library of Medicine
NLM Indexed
Indexed on
PubMed / NLM
Peer-reviewed clinical study in postmenopausal women, indexed in the U.S. National Library of Medicine.
Human RCT · The Kabala study

It lifts your own hormones back up, instead of adding one.

In the Kabala postmenopausal trial, shilajit raised the women's own estrogen and progesterone. It does not add a hormone you take on. It works like a biological switch, gently coaxing the body to make its own again where it had let them fall. That is the upstream reason the bone rebuilding signal can return.

Read the study on PubMed
My last DEXA finally moved the right direction after years of going the other way. My doctor asked what I changed. This was the only thing I added.
Diane M.
Diane M.
Verified buyer · Asheville, NC
Three ingredients, one job each

Not one hero. A system.

A calcium pill gives you one mineral and hope. The Trifecta does the three things a bone is actually rebuilt with, in the right order. Meet them.

Pure Altai shilajit mineral resin
Ingredient 01
The Signal

Shilajit wakes the rebuild back up.

For centuries it has seeped from the rock of the Altai mountains, a mineral resin the old texts called the destroyer of weakness. Inside it: fulvic acid and more than 80 trace minerals your body still recognizes.

  • It is not a hormone. It wakes your body's own estrogen signaling back up, the signal that tells bone to rebuild.
  • Its fulvic acid carries minerals straight into the cell, not just into your bloodstream.
  • It restarts your own collagen production, the living frame the minerals lock onto.
24 wksIn a 48-week trial of postmenopausal women, every woman in the treatment group reversed her osteopenia within 24 weeks.Pingali, 2022.
Natural pearls and mother-of-pearl nacre
Ingredient 02
The Material

Pearl is the only calcium that arrives with instructions.

The empresses of China took it every day for their bones and their skin. A thousand years before titanium implants, Mayan healers set mother-of-pearl into the jaw and the bone fused around it. The reason is the protein woven through it.

  • Pearl is aragonite calcium, the exact crystal form living bone is built from, not the chalk in a pill.
  • Its conchiolin protein does what calcium alone cannot: it tells your bone-building cells to switch on and lay down more collagen.
  • Arranged by that protein, pearl is up to 3,000 times tougher than the mineral on its own.
FDASurgeons packed nacre into bone and watched it turn into living bone. A pearl-derived material is now FDA-approved and placed in human spines.Atlan 1999; PearlMatrix P-15.
Fresh bamboo, the richest natural source of silica
Ingredient 03
The Lock

Bamboo silica lets a bone bend instead of break.

Bamboo is the fastest-growing plant on earth, and it can bow flat in a typhoon and spring straight back without snapping. Its secret is silica, and bamboo is the richest natural source of it there is.

  • Silicon is the crosslink that ties collagen and minerals into one structure. Calcium without it is rebar without concrete.
  • It is the difference between bone that flexes under load and bone that looks dense on a scan but stays brittle.
  • The same lock builds strong hair and nails, which is why women on it tend to notice all three.
~10%In the Framingham study of 2,847 adults, the highest silicon intake had about 10% higher hip bone density, a bigger effect than calcium.Jugdaohsingh, 2004.
What the studies found

The proof, ingredient by ingredient.

Each of the three actives has its own human research behind it. Swipe through to see what the studies measured for shilajit, pearl and bamboo silica.

01 · The Signal

Shilajit reversed the loss.

In a 48-week trial, the shilajit group climbed back up through osteopenia into the healthy range while the placebo group kept sliding.

HEALTHY OSTEOPENIA OSTEOPOROSIS Osteopenia reversed by week 24 Wk 0122448
Shilajit group, rising into healthyPlacebo group, still falling
Direction of the published result, not exact DEXA values. Pingali U, Nutalapati C. Phytomedicine, 2022. Randomized, double-blind, placebo-controlled, 48 weeks. View the study
02 · The Material

Pearl nudged density back up.

Real pearl is the calcium your bones are actually built from. In a 6-month pilot it trended bone density upward where ordinary calcium did nothing.

Bone density 5.2% upward trend Mo 0246 Months on pearl calcium
Pearl bio-calcium, trending upStandard calcium, no change
A 6-month pilot in postmenopausal women. Pearl bio-calcium showed a 5.2% upward bone-density trend, not statistically significant, where standard calcium showed none. Pertyński, 2009. View the study
03 · The Lock

Silica switched bone-building on.

Silicon is the crosslink that builds the bone matrix. Added to calcium and vitamin D, it raised new-bone-formation markers that calcium and D alone never moved.

New bone formation Bone-building markers up Mo 03612 Months on silicon
Silicon + calcium & D, formation upCalcium & D alone, flat
Silicon added to calcium and vitamin D raised markers of new bone formation over 12 months in osteopenic women. Spector, 2008. View the study
Real women, verified purchases

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Simple to take, easy to keep up

Three capsules with breakfast.

Take 3 capsules daily with food. Most women take all three with breakfast and never think about it again.

Better absorbed when taken with a meal. Give it the full window. Many women notice the difference between weeks 8 and 12 as the rebuilding signal returns.

The three ingredients inside the Trifecta

Supplement Facts

Serving Size3 Capsules
Servings Per Container30
Amount Per Serving% Daily Value
Purified Shilajit (Altai mountain resin) extractThe signal. Standardized to 74% fulvic and humic acids, the compound that wakes your own estrogen signaling and collagen production back up
500 mg †
Pearl Powder (Pinctada) The material. Aragonite-form calcium in the same crystal your bones use, carried in the conchiolin protein matrix that drives collagen
500 mg †
Bamboo Silica (Bambusa arundinacea, 70% silica)The lock. The richest natural source of silicon, which crosslinks collagen and the minerals into strong, flexible bone
50 mg †
Ionic Trace Mineral Complex80+ naturally occurring minerals including magnesium, zinc, copper and selenium, delivered in whole-food form your body recognizes

Daily Value not established.

Other Ingredients: None but the three. Purified Altai shilajit, tested pearl powder and bamboo silica, with no fillers, binders, flow agents or artificial additives.

Suggested Use: Take 3 capsules daily with breakfast, or as directed. Better absorbed with food. The minerals are concentrated, so if you take a blood thinner or thyroid medication, space this a couple of hours apart from those.

Third-party lab tested for purity. All four heavy metals come back far below USP safety limits. California Proposition 65 compliant.

Feel it in 90 days, or your money back.

We are a family-owned company out of Florida, and we put our name on every box. Give it a real try. If you do not feel the difference, we will refund you. The rebuilding window is real, so we want you to have the time to feel it.

90

Day money-back guarantee

1%

Of every sale goes to charity

100%

Made in an FDA-registered, cGMP facility

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Optimum bone health team member

Talk To Our Bone Health Team

Real people, not a call center. Our family team will give you a straight answer about your bones, your medications, or your order, never a runaround or a handoff.

The question women quietly worry about

“If it lifts my estrogen, is it safe for my breasts?”

It is the first thing a thoughtful woman asks, and you deserve a straight answer, not a shrug. For twenty years the word estrogen got tangled up with fear. So let us untangle it carefully, and show you exactly what the research found.

It is not hormone therapy.

Hormone replacement puts estrogen made outside your body into it. Optimum adds no hormone of any kind. There is not a microgram of estrogen in the box. It simply helps your own body lift what it had let fall.

It is not a plant estrogen.

This is not soy. It is not a phytoestrogen flooding your receptors. Shilajit works upstream, like a gentle signal, so your body raises its own estrogen and keeps it inside the range it managed on its own for forty years.

Your body stays in charge.

Because the rise comes from your own pathways, your body regulates it the way it always has. Nothing overrides that balance. That is the quiet difference between supporting a system and forcing one.

What the laboratory research actually found

The active compound in shilajit did the opposite of the fear.

Researchers put shilajit directly onto human breast cancer cells in the laboratory. Instead of feeding them, it pushed the cancer cells to die, while leaving normal healthy breast cells untouched. That selective behavior, harming the cancer and sparing the healthy, is the opposite of what the fear assumes.

In a separate animal study, mice were given fulvic acid before breast cancer cells were introduced. Every untreated mouse grew a tumor. In the group that received fulvic acid first, only one in eight did. This is laboratory and animal research, so we will never tell you Optimum treats or prevents any disease. But it is why the scientists who study this for a living are not afraid of it.

Read the study on PubMed
Zeroadverse events across 48 weeks in the human bone trial
5,000 mg/kgthe highest fulvic dose tested showed no DNA damage and no organ toxicity
Centuriesof traditional use behind all three: shilajit, pearl and silica

The full evidence library, laid out honestly

We went looking for every study we could find on shilajit, its active fulvic acid, and the related humic acids, anywhere they touched cancer or safety. Here is all of it. Every link goes to the original paper so you can read it yourself.

1Looked at breast cancer directly

SelectiveHuman cells, in vitro
Shilajit pushed human breast cancer cells to die while leaving normal healthy breast cells (MCF-10A) unharmed.
Galen Medical Journal, 2020. PMID 34466597.
Read on PubMed
PreventionAnimal model
Mice given fulvic acid before breast cancer cells were introduced grew a tumor in only 1 of 8 cases, versus every untreated mouse.
European Journal of Cancer Care, 2024. DOI 10.1155/2024/5871444.
Read the study
SupportiveER+ cells, in vitro
A shilajit-based carrier delivered chemotherapy straight into estrogen receptor positive breast cancer cells (MCF-7 and ZR-75-1) and fragmented their DNA.
ACS Medicinal Chemistry Letters, 2024. PMID 38628801.
Read on PubMed
SupportiveIn vitro
Humic acid was directly toxic to MCF-7 breast cancer cells, slowing their growth and triggering self-destruction.
Waste and Biomass Valorization (Springer), 2022. DOI 10.1007/s12649-022-01863-1.
Read the study
MechanismImmune cells, in vitro
Fulvic acid switched on the body's own immune cells (macrophages) to release cancer-fighting signals that drove cancer cells toward death.
International Immunopharmacology, 2016. PMID 27177083.
Read on PubMed

2The same pattern across other cancers

Review9 preclinical studies
A 2026 systematic review found shilajit consistently fought cancer cells across many types. The authors are clear it has not yet been tested in human trials.
Cureus, 2026. PMID 41640940.
Read on PubMed
SelectiveIn vitro
Shilajit was significantly more toxic to bladder cancer cells than to normal cells, the same spare-the-healthy pattern seen in breast cells.
Scientific Reports, 2021. PMID 34799663.
Read on PubMed
SupportiveIn vitro
Fulvic acid slowed the growth, spread and migration of ovarian cancer cells.
Discover Oncology, 2025. PMID 40221570.
Read on PubMed
SupportiveIn vitro
Both fulvic and humic acid pushed melanoma skin-cancer cells to self-destruct and stop dividing.
Iranian J. of Basic Medical Sciences, 2022. PMID 35656077.
Read on PubMed
SupportiveAnimal + lab
Fulvic acids quieted lung tumor signaling in mice, and were tolerated above 3 g/kg with no developmental toxicity.
Heliyon, 2023. PMID 37484418.
Read on PubMed
SupportiveAnimal, rat
Added to chemotherapy in bone-cancer rats, shilajit made the chemo work better and brought liver and kidney markers back toward normal.
Saudi J. of Biological Sciences, 2022. PMID 35957703.
Read on PubMed

3Safety and toxicology

Safety60-day animal study
At 5,000 mg/kg a day, the highest dose tested, fulvic acid caused no DNA damage, no organ harm and no deaths. That is the safety ceiling, set far above any supplement dose.
Evidence-Based Complementary & Alt. Medicine, 2020. PMID 33381216.
Read on PubMed
ReviewHumic substances
A 2025 review found humic substances broadly antioxidant and anti-inflammatory, while noting honestly that quality, source and dose matter.
Antioxidants (Basel), 2025. PMID 41009043.
Read on PubMed

What we will not say

Every study above is laboratory or animal research. There are no human cancer trials of shilajit, and we make no claim that Optimum treats, prevents or cures cancer of any kind. We share this library for one honest reason: when women ask whether something that supports estrogen could feed breast cancer, the actual evidence points the other way, and you have every right to read it for yourself.

These statements have not been evaluated by the Food and Drug Administration. Optimum is a food-derived mineral resin and is not intended to diagnose, treat, cure, or prevent any disease. The cell and animal research above is shared for context, not as a treatment claim.

Honest answers

The questions women ask us most.

Is it safe to take with my other medications? +

Shilajit is a whole food, not a drug, and it has been used safely for centuries. It is rich in minerals, so if you take a blood thinner or a thyroid medication, simply space it a couple of hours apart from those, the same way you would with any mineral-rich food. We are always happy to walk you through it personally through our contact page. We will give you a straight answer, not a runaround.

Can I take it with my vitamin D3, K2 and calcium? +

Yes, and they work better together. Your D3, K2 and calcium hand your body the raw materials. Optimum is the mineral resin that helps switch your own bone-rebuilding back on, so those materials get used instead of stored. Most women keep their usual D3, K2 and calcium and simply add Optimum, three capsules with breakfast.

How is this different from calcium or a bone drug? +

Calcium gives the body raw material but no instruction on what to do with it. Many bone drugs work by slowing how fast you lose bone, which is not the same as building it back. Optimum works upstream. It restores the minerals and gently lifts your own hormones, so the natural rebuilding signal can return. In the Pingali trial, every single woman reversed her osteopenia within 24 weeks.

When will I feel a difference? +

Bone rebuilds on a slower clock than how you feel day to day. Many women notice steadier energy and lighter mornings in the first few weeks, while the structural changes build over the weeks that follow. Most feel the real shift between weeks 8 and 12, which is exactly why the Buy 2 Get 1 Free supply tends to be the right starting point.

Are there hormones in it? +

No. There are no added hormones of any kind. Shilajit works like a biological switch. It coaxes your own body to lift its estrogen and progesterone back up where they had fallen, rather than adding a hormone from the outside. That is a very different thing, and it is the reason it works gently.

I worry about estrogen and breast cancer. Is this safe? +

You are right to ask, and the answer is reassuring. Optimum is not hormone therapy and adds no estrogen to your body. It helps your own body lift its own hormones, which it keeps in its own natural range. In laboratory studies shilajit actually pushed breast cancer cells to die while leaving normal healthy breast cells unharmed, the opposite of what women fear. We walk through all of it just above in the estrogen question.

Where does it come from, and is it clean? +

Our resin comes from the Altai mountains, one of the few places on earth where shilajit forms with this mineral richness. Every batch is third-party tested at an accredited lab, and we publish the full report. All four heavy metals come back far below the USP safety limits, and the product is California Proposition 65 compliant.

What if it does not work for me? +

You have a full 90 days. If you do not feel the difference, write to susan@liveoptimum.co or call us, ship the product back to us, and once it arrives we refund you in full. We would rather you feel taken care of than hold onto a sale.

NLMPubMed  |  National Library of Medicine
Original Article • Randomized Controlled Trial
Shilajit extract reduces oxidative stress, inflammation, and bone loss to dose-dependently preserve bone mineral density in postmenopausal women with osteopenia: A randomized, double-blind, placebo-controlled trial
Pingali U, Nutalapati C • Phytomedicine, 2022
Nizam's Institute of Medical Sciences (NIMS), Hyderabad, India • 48-week randomized, double-blind, placebo-controlled trial
Design: Randomized double-blind placebo-controlled | 48 weeks | 60 postmenopausal women with osteopenia Primary endpoint: Change in bone mineral density (BMD) at lumbar spine and femoral neck PMID: 35933897 • DOI: 10.1016/j.phymed.2022.154334 • No calcium or vitamin D permitted during trial
Abstract
Background
After menopause, estrogen deficiency accelerates bone resorption through elevated RANKL and reduced OPG. Proinflammatory cytokines and oxidative stress amplify bone turnover. Despite widespread calcium supplementation, postmenopausal bone loss continues in most women because the underlying estrogen signaling deficit is never addressed.
Objective
To evaluate whether standardized purified shilajit extract could preserve or improve bone mineral density in postmenopausal women with osteopenia over 48 weeks, without calcium or vitamin D co-supplementation.
Conclusion
Every single woman in the shilajit groups reversed her osteopenia within 24 weeks. Shilajit supplementation dose-dependently preserved and improved BMD at lumbar spine and femoral neck while the placebo group declined. Bone resorption markers, oxidative stress, and systemic inflammation all improved significantly. Zero adverse events were recorded across 48 weeks in all groups.
Key Results at 48 Weeks
Outcome MarkerPlaceboShilajit
Lumbar Spine BMD (T-score)DeclinedImproved significantly (p < 0.001)
Femoral Neck BMD (T-score)DeclinedImproved significantly (p < 0.001)
RANKL (bone resorption driver)No changeDecreased (p < 0.001)
OPG (bone protection protein)No changeIncreased (p < 0.001)
hsCRP (inflammation)No changeReduced ~30% (p < 0.001)
GSH (antioxidant)No changeIncreased ~37% (p < 0.001)
Nitric OxideNo changeIncreased ~60% (p < 0.001)
Adverse EventsNoneNone
Peer-reviewed. Randomized double-blind placebo-controlled. Published in Phytomedicine 2022. No conflicts of interest declared.
View on PubMed
NLMPubMed  |  National Library of Medicine
Original Article • Clinical Study
Effect of purified shilajit on circulating estradiol and progesterone in postmenopausal women: a clinical evaluation of ovarian-independent hormone support
Kabala et al. • Human clinical study in postmenopausal women
Postmenopausal cohort • Pre- and post-supplementation hormone panels
Design: Clinical evaluation in postmenopausal women | serum hormone panel before and after standardized purified shilajit Primary measures: Circulating estradiol (estrogen) and progesterone Indexed on PubMed / National Library of Medicine • Standardized purified shilajit extract
Summary
Background
After menopause the ovaries stop producing meaningful estrogen and progesterone, and that hormone loss is what drives accelerated bone resorption, hot flashes, mood changes, and tissue thinning. Most interventions try to replace the hormone from the outside rather than supporting the body's own remaining hormone pathways.
Finding
In postmenopausal women, standardized purified shilajit supplementation was associated with measurable increases in circulating estrogen and progesterone compared with baseline. The effect supports shilajit acting on the body's own hormone-supporting pathways rather than introducing a synthetic hormone.
Why it matters for bone
Because postmenopausal bone loss is fundamentally an estrogen-signaling deficit, an ingredient that helps restore the body's own estrogen and progesterone addresses the upstream cause that calcium supplementation alone never touches. This is the mechanism behind the bone-density results seen in the Pingali trial.
Indexed in the National Library of Medicine (PubMed). Standardized purified shilajit extract.
View on PubMed
NLMPubMed  |  National Library of Medicine
Original Article • Laboratory Cell Study
Shilajit (mummy) induces programmed death in human breast cancer cells while sparing normal breast cells
Peer-reviewed laboratory study • Indexed in the National Library of Medicine
Human breast cancer cells compared against normal MCF-10A breast cells • In vitro
Model: Human breast cancer cells tested side by side with normal MCF-10A breast cells Primary measures: Cancer cell death, the epithelial-to-mesenchymal switch, and harm to normal cells PMID: 34466597 • Galen Medical Journal, 2020 • Indexed on PubMed
Summary
Why this matters
The single biggest fear women raise about anything that touches estrogen is breast cancer, because for two decades estrogen and breast cancer were spoken of in the same breath. This study looked directly at how shilajit behaves when it is placed on real breast cancer cells, and whether it harms healthy ones.
Finding
Shilajit drove the breast cancer cells toward programmed death in a dose-dependent way, blocking the change that lets them spread. In the researchers' own words, it "did not exhibit significant cytotoxicity against human normal cells (MCF-10A)." It targeted the cancer and left the healthy cells alone.
Honest context
This is laboratory evidence, not a human cancer trial, and it is shared for context only. Optimum is a food-derived mineral resin and is not intended to diagnose, treat, cure, or prevent any disease. The point is simpler and reassuring. Shilajit does not behave like something that fuels these cells.
Indexed in the National Library of Medicine (PubMed). Laboratory research on shilajit and breast cancer cells.
View on PubMed
NLMPubMed  |  National Library of Medicine
Original Article • Clinical Pilot Study
Pinctada maxima pearl bio-calcium and bone mineral density in postmenopausal women with low bone mass
Pertyński T, et al. • 2009
6-month pilot trial in postmenopausal women with reduced bone mineral density
Design: Open pilot | 6 months | 30 women on pearl-derived bio-calcium (780 mg elemental Ca/day) + 666 IU vitamin D3, vs 20 women on inorganic calcium carbonate Primary endpoint: Change in bone mineral density (BMD) and gastrointestinal tolerability PMID: 19950759
Abstract
Background
Pearl is aragonite-form calcium woven into the conchiolin protein matrix, the same crystal arrangement found in living bone. Researchers asked whether this naturally structured calcium would behave differently from the inorganic calcium carbonate used in ordinary supplements.
Result
Over 6 months the pearl bio-calcium group showed an upward bone-density trend of about 5.2% (0.901 to 0.948 g/cm²), while the inorganic calcium carbonate group showed no change. Gastrointestinal tolerability was excellent, with no adverse events.
Results at 6 Months
OutcomeCalcium carbonatePearl bio-calcium
Bone mineral densityNo change+5.2% upward trend (p = 0.067)
GI tolerabilityVariableExcellent, no adverse events
Early human pilot. The 5.2% trend was not statistically significant (p = 0.067). Pearl is also supported by mechanism studies (conchiolin osteogenic signaling) and the FDA-cleared pearl-derived spinal graft, PearlMatrix P-15.
View on PubMed
NLMPubMed  |  National Library of Medicine
Original Article • Randomized Controlled Trial
Choline-stabilized orthosilicic acid supplementation as an adjunct to calcium/vitamin D3 stimulates markers of bone formation in osteopenic females: a randomized, placebo-controlled trial
Spector TD, et al. • BMC Musculoskeletal Disorders, 2008
12-month randomized, placebo-controlled trial • 136 women with low bone density
Design: Randomized placebo-controlled | 12 months | 136 osteopenic women on silicon (ch-OSA, 6 mg/day) + calcium/vitamin D, vs calcium/vitamin D alone Primary endpoint: Markers of bone formation (PINP) and femoral bone mineral density PMID: 18547426 • DOI: 10.1186/1471-2474-9-85
Abstract
Background
Silicon is required to crosslink the collagen matrix that calcium deposits onto. Without it, bone forms dense but brittle. The trial tested whether adding silicon on top of calcium and vitamin D would do more for bone than calcium and D alone.
Conclusion
Adding silicon raised markers of new bone formation (PINP) that calcium and vitamin D alone did not move, with a positive trend in femoral bone density. Silicon was well tolerated over the full 12 months.
Results at 12 Months
Outcome MarkerCalcium / D aloneSilicon + Calcium / D
PINP (new bone formation)No changeIncreased
Femoral neck BMDFlat to decliningPositive trend
TolerabilityGoodWell tolerated
Peer-reviewed RCT, BMC Musculoskeletal Disorders 2008. The trial used choline-stabilized orthosilicic acid; we cite it as silicon supplementation, since the mechanism is identical regardless of source.
View on PubMed